Thursday, March 14, 2013

Parkinson's


PARKINSONS

Parkinson’s disease was one of the major neuro-degenerative diseases covered in the 2003 US Federal Patent for Cannabidiol.
There are a lot of studies showing benefit with symptoms of tremor and spasticity and I have listed some below.
In my experience with Parkinson’s patients, they are often benefitted from rich CBD medicines but can be very sensitive to THC. In addition, with any neuromotor illness, there is a large amount of performance anxiety associated with everything from speech to any movement. This is worst when in front of people and is so very understandable.
One of the many benefits from using CBD in these patients is reducing their anxiety level. When they are truly calm and a little “less stiff”, they become more comfortable and then become more confident allowing themselves to receive the maximum benefit from any of their medications.
References:
1.Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson’s disease.
Carroll CB, Zeissler ML, Hanemann CO, Zajicek JP.
Neuropathol Appl Neurobiol. 2012 Oct;38(6):535-47. doi: 10.1111/j.1365-2990.2011.01248.x.
PMID: 22236282 [PubMed - indexed for MEDLINE]
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2.Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson’s disease.
García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee R, Fernández-Ruiz J.
Br J Pharmacol. 2011 Aug;163(7):1495-506. doi: 10.1111/j.1476-5381.2011.01278.x.
PMID: 21323909 [PubMed - indexed for MEDLINE] Free PMC Article
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3.Cannabidiol: a promising drug for neurodegenerative disorders?
Iuvone T, Esposito G, De Filippis D, Scuderi C, Steardo L.
CNS Neurosci Ther. 2009 Winter;15(1):65-75. doi: 10.1111/j.1755-5949.2008.00065.x. Review.
PMID: 19228180 [PubMed - indexed for MEDLINE]
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4.Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.
Zuardi AW.
Rev Bras Psiquiatr. 2008 Sep;30(3):271-80. Review.
PMID: 18833429 [PubMed - indexed for MEDLINE] Free Article
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5.Cannabidiol for the treatment of psychosis in Parkinson’s disease.
Zuardi AW, Crippa JA, Hallak JE, Pinto JP, Chagas MH, Rodrigues GG, Dursun SM, Tumas V.
J Psychopharmacol. 2009 Nov;23(8):979-83. doi: 10.1177/0269881108096519. Epub 2008 Sep 18.
PMID: 18801821 [PubMed - indexed for MEDLINE]
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6.Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease.
Lastres-Becker I, Molina-Holgado F, Ramos JA, Mechoulam R, Fernández-Ruiz J.
Neurobiol Dis. 2005 Jun-Jul;19(1-2):96-107.
PMID: 15837565 [PubMed - indexed for MEDLINE]

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